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Our publications

Radzisheuskaya A*‡, Peña-Rømer I*, Lorenzini E, Koche R, Zhan Y, Shliaha PV, Cooper A, Fan Z, Shlyueva D, Johansen JV, Hendrickson RC, Helin K‡ (2023) The alternative Nucleosome Remodeling Factor complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions. EMBO J. e114221

*Equal contribution, ‡ Co-corresponding

EMBO synopsis figure_edited.jpg

Alex's publications before joining the ICR

First-author research publications:

1.  Radzisheuskaya A, Shliaha PV, Grinev V, Shlyueva D, Damhofer H, Koche R, Gorshkov V, Kovalchuk S, Zhan Y, Rodriguez KL, Johnstone AL, Keogh M-C, Hendrickson RC, Jensen ON, Helin K. (2021) Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcriptional regulation and cellular homeostasis. Molecular Cell. 81(8):1749-1765.

2.  Radzisheuskaya A, Shliaha PV, Grinev V, Lorenzini E, Kovalchuk S, Shlyueva D, Gorshkov V, Hendrickson RC, Jensen ON, Helin K. (2019) PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia. Nat Struct Mol Biol. 26(11):999-1012.​

3.  Radzisheuskaya A, Shlyueva D, Müller I and Helin K. (2016) Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression. Nucleic Acids Res. 44(18): e141.​

4.  Radzisheuskaya A, Chia G le B, dos Santos RL, Theunissen TW, Castro LF, Nichols J, Silva JC. (2013) A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages. Nat Cell Biol. 15(6):579-90.

5.  Pasque V *, Radzisheuskaya A*, Gillich A, Halley-Stott RP, Panamarova M, Zernicka-Goetz M, Surani MA, Silva JC. (2012) Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency. J Cell Sci. 125(Pt 24):6094-104.

*Equal contribution

Other research publications:

1. Damhofer H, Radzisheuskaya A, Helin K. (2021) Generation of locus-specific degradable tag knock-ins in mouse and human cell lines. STAR Protocols. 2:100575

2.  Müller I, Moroni AS, Shlyueva D, Sahadevan S, Schoof EM, Radzisheuskaya A, Højfeldt JW, Tatar T, Koche RP, Huang C, Helin K. (2021) MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells. Nat Commun. 12(1):3034.

3.  Tremble KC, Stirparo GG, Bates LE, Maskalenka K, Stuart HT, Jones K, Andersson-Rolf A, Radzisheuskaya A, Koo BK, Bertone P, Silva JCR. (2021) Sox2 modulation increases naïve pluripotency plasticity. iScience. 24(3):102153. 

4.  Pastore F, Bhagwat N, Pastore A, Radzisheuskaya A, Karzai A, Krishnan A, Li B, Bownan RL, Xiao W, Viny AD, Zouak A, Park YC, Cordner KB, Braunstein S, Maag JL, Grego A, Mehta J, Wang M, Lin H, Durham BH, Koche RP, Rampal RK, Helin K, Scherle P, Vaddi K, Levine RL. (2020) PRMT5 inhibition modulates E2F1 methylation and gene regulatory networks leading to therapeutic efficacy in JAK2V617F mutant MPN. Cancer Discov. 10(11):1742-1757.

5.  Garland W, Comet I*, Wu M*, Radzisheuskaya A*, Rib L, Vitting-Seerup K, Lloret-Llinares M, Sandelin A, Helin K, Jensen TH. (2019) A Functional Link Between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2. Cell Rep. 29(7):1800-1811.e6.

 *Equal contribution

6.  Stuart HT, Stirparo GG, Lohoff T, Bates LE, Kinoshita M, Lim CY, Sousa EJ, Maskalenka K, Radzisheuskaya A, Malcolm AA, Alves MRP, Lloyd RL, Nestorowa S, Humphreys P, Mansfield W, Reik W, Bertone P, Nichols J, Göttgens B, Silva JCR. (2019) Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell Stem Cell.25(3):388-406.e8

7.  Pedersen MT, Kooistra SM, Radzisheuskaya A, Laugesen A, Johansen JV, Hayward DG, Nilsson J, Agger K and Helin K. (2016) Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC selfrenewal and early development. EMBO J. 35(14):1550-64.

8.  Dos Santos RL, Tosti L, Radzisheuskaya A, Caballero IM, Kaji K, Hendrich B, Silva JCR. (2014) MBD3/NuRD Facilitates Induction of Pluripotency in a Context-Dependent Manner. Cell Stem Cell. 15(3):392.

9.  Christophorou MA, Castelo-Branco G, Halley-Stott RP, Oliveira CS, Loos R, Radzisheuskaya A, Mowen KA, Bertone P, Silva JC, Zernicka-Goetz M, Nielsen ML, Gurdon JB, Kouzarides T. (2014) Citrullination regulates pluripotency and histone H1 binding to chromatin.

Nature. 507(7490):104-8.

10.  Stuart HT, van Oosten AL, Radzisheuskaya A, Martello G, Miller A, Dietmann S, Nichols J, Silva JC. (2014) NANOG amplifies STAT3 activation and they synergistically induce the naive pluripotent program. Curr Biol. 24(3):340-6.

11.  Davies OR, Lin CY, Radzisheuskaya A, Zhou X, Taube J, Blin G, Waterhouse A, Smith AJ, Lowell S. (2013) Tcf15 primes pluripotent cells for differentiation. Cell Rep. 3(2):472-84.

12.  Theunissen TW, Costa Y, Radzisheuskaya A, van Oosten AL, Lavial F, Pain B, Castro LF, Silva JC. (2011) Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain. Development. 138(22):4853-65.

Review:

Radzisheuskaya A, Silva JC. (2014) Do all roads lead to Oct4? The emerging concepts of induced pluripotency. Trends Cell Biol. 24(5):275-84.

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